논문

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Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients

Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients
학술지명 European Neurology ISSN 0014-3022
SCI 유무 SCI 게재연월 2013-07 Vol. 70 No. 1
표준화된 순위정보영향력지수 32.63 IF 1.5 Citation -

Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients
저자 EunYeon Joo, HyunJin Noh, JeongSik Kim, DaeLim Koo, Daeyoung Kim, KyoungJin Hwang, SungTae Kim, SeungBong Hong, EunYeon Joo, JongMin Lee, SeungBong Hong
초록
Aims: To estimate the effect of levetiracetam (LEV) on cognitive function and mood status in newly diagnosed epilepsy patients. Methods: Fifty-five drug-naïve epilepsy patients (M:F ratio = 31: 24; mean age = 30.9 years) were included. All patients underwent two neuropsychological (NP) tests, one before receiving LEV and then another 12.9 ± 5.0 months after starting LEV monotherapy. We evaluated general cognitive function, verbal/visual attention and memory, linguistic and visuospatial functions, frontal lobe function, and mood status. Repeated-measures regression and generalized estimating equation models were applied to assess the effects of all the confounding variables such as seizure control, average LEV dose, duration of epilepsy, inter-test interval, and subtype of epilepsy syndrome. Results: LEV monotherapy over 1 year revealed significant improvements in the following domains of NP tests with the correction of possible confounding variables: verbal and visual attention, psychomo-tor speed, mental flexibility, executive function, verbal fluency and word generation. No NP domains showed any significant decrease. Conclusion: Our study suggested that LEV monotherapy had no harmful effect on cognitive function in drug-naïve patients with epilepsy.
keyword Cognitive function, Epilepsy, Levetiracetam, Antiepileptic drug, Neuropsychological test

Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients
과제명 공존감 지원 실감교류 확장공간 소프트웨어 프레임워크 기술
연구기관 실감교류인체감응솔루션연구단 연구책임자 유범재